to evaluate correspondence of perimetry and optical coherence tomography in early detection of hydroxychloroquine retinopathy.

This comparative cross-sectional study was done to evaluate diagnostic tests that can detect early macular lesions.138 patients (276 eyes) who were on hydroxychloroquine treatment and were reffered to Amiralmomenin hospital regarding consultaion on continuing the drug,were consecutively included in the study until the sample volume was reached. Complete eye examination ( including best corrected visual acuity and funduscopy ), perimetry 10-2 and SD-OCT were performed for all patients

: these two methods had Agreement in detecting early retinopathy in only 4% (11 eyes) of all cases(P=0.39,kappa=-0.047). Out of 43 eyes (15.6%) which were diagnosed with early retinopathy by SD-OCT, 18 eyes (41.9%) were diagnosed with moderate-advanced retinpathy and 14 eyes (32.6%) were reported as normal by perimetry.Out of 86 eyes (31.3%) which were diagnosed with early retinopathy by perimetry, ,in only 11 eyes (12.8%) based on SD-OCT ,early retinopathy and 75 eyes (78.2%) were reported normal.

Based on this study, two methods don’t have Agreement in showing early macular lesions. Also, in this study, the percentage of detecting early retinopathy was 31.2% by perimetry and 15.6% by SD-OCT (perimetry twofold more than SD-OCT) and this difference was significant based on MC Nemar test (P<0.0001).