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مقاله
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Abstract
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Title:
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In Vivo Evaluation of Efficacy of Systemic Administration of Oral Slow Release Diclofenac Sodium on Intravitreal Concentration
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Author(s):
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Yunes Panahi, Pharm D, PhD; Mostafa Naderi MD; Khosrow Jadidi MD; Mojtaba Abrishami, MD
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Presentation Type:
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Poster
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Subject:
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Physiology/Pharmacology
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Others:
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Presenting Author:
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Name:
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Mojtaba Abrishami
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Affiliation :(optional)
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Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
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E mail:
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mojtaba_abrishami@yahoo.com
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Phone:
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05118433192
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Mobile:
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09155207987
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Purpose:
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We aimed to assess the efficacy of slow release oral diclofenac sodium in preparing intravitreal concentration in experimental model of chemical injured eyes.
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Methods:
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In an experimental double-masked clinical trial, right eyes of 24 albino rabbits were chemically injured by 1 N NaOH. One hour after chemical injury, 10 cc suspension gavage containing 100 mg slow release diclofenac sodium was administered in all cases. 2, 4, 6, 12, 24, 48 hours after gavage, vitreous samples were obtained in all cases. Intravitreal concentration of diclofenac sodium was evaluated in all samples using HPLC method.
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Results:
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Iintravitreal diclofenac levels by oral intake were enhanced by the inflammation. After 6 hours, diclofenac concentration was not significant in the vitreous and reduced below 1μg/ml.
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Conclusion:
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Diclofenac is delivered to the inflamed eye more than healthy eye. It seems that by oral diclofenac, it is possible to make a significant intravitreal concentration.
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Attachment:
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