To compare anterior segment parameters in patients with central retinal vein occlusion (CRVO) with normal control subjects by anterior segment optical coherence tomography (AS-OCT)

In this coss-sectional case-control study, 42 eyes from 21 patients with unilateral CRVO and 21 eyes from 21 age- and sex-matched healthy control subjects were recruited. Study eyes were divided into three groups: involved eyes of CRVO patients(CRVO eyes), fellow eyes of CRVO patients (fellow eyes) and control eyes. Complete ocular examination and AS-OCT were performed for each eye. The AS-OCT parameters(anterior chamber depth [ACD],scleral spur angle[SSA],angle opening distance at 500μm and 750μm from scleral spur [AOD500 and 750] and trabecular-iris space area at 500μm and 750μm from scleral spur [TISA500 and 750]) and the rate of narrow angles(based on gonioscopy) in CRVO and fellow eyes were compared with control eyes

The mean(SD) age of the patients and the control group were 60.09(9.43) and 59.52(6.66), respectively.The mean IOP in both eyes of the patients were significantly higher than the control eyes. All AS-OCT parameters were significantly different among the 3 groups. Comparing with the control eyes, CRVO eyes had shallower ACD(2.53mm vs. 2.85mm; p=0.002) and narrower AS-OCT angle parameters(SSA, AOD500 and 750, TISA 500 and 750). Fellow eyes had also shallower ACD(2.56mm vs. 2.85mm; p=0.005) than control eyes and smaller SSA, AOD500 and AOD750. Five (23.8%) CRVO patients were diagnosed with narrow angles in both eyes based on gonioscopy,whereas no eye in the control group had narrow angles(p=0.05).

Imaging with AS-OCT showed that CRVO patients had shallower ACD and narrower angle parameters in both eyes in comparison with control eyes. Furthermore, CRVO patients had higher rates of narrow angles on gonioscopic examination.