The aim of our study was to evaluate corneal properties including corneal thickness, biomechanical parameters, endothelial and keratocyte density in patients with history of treated unilateral primary congenital glaucoma (PCG) and compare them with fellow unaffected eye.

LENSTAR was performed to evaluate ocular biometric parameters: Axial length, anterior chamber depth (ACD), mean keratometry, astigmatism and central corneal thickness (CCT) in 12 patients with history of treated unilateral PCG. Corneal hysteresis (CH), corneal resistance factor (CRF) were measured with the aid of ocular response analyser. Slit scanning confocal microscopy was used for the evaluation of stromal keratocyte and endothelium densities. Paired t-test and Wilcoxon singed-rank test were used for statistical analysis. P values <0.05 were considered statistically significant.

Axial length was significantly higher in the affected eyes compared to the fellow eyes (p<0.05). Mean aqueous depth and anterior chamber depth were increased in affected eyes compared to the fellow eyes. Mean keratometry in the affected eyes was significantly flatter compared to the fellow eyes (p<0.05). We identified negative correlation between axial length and mean keratometry (p<0.05). There is not any significant difference of CCT between the affected and fellow eyes. CH was significantly reduced in the affected eyes compared to the fellow eyes (p< 0.05). CRF was reduced in the affected eyes compared to the fellow eyes; however, this difference was not statistically significant. Mean keratocyte density in the anterior, middle and posterior corneal stroma were reduced in the affected eyes compared to the fellow eyes, however, the difference was not statistically significant. Mean endothelial cell density was reduced in the affected eyes (p<0.05).

our results showed that corneal biomechanical parameters are different in the affected eye in patients with history of treated PCG. Altered corneal biomechanics may affect IOP measurement by Goldman applantion tonometry and the outcomes of keratorefractive surgery in PCG patients. Slit-scanning confocal microscopy showed significant difference of endothelial density in the affected eyes. We suggest patients with history of treated PCG in preoperative evaluation for cataract surgery be evaluated for endothelial cell density.