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مقاله
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Abstract
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Title:
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Adiponectin versus Bevacizumab in decreasing corneal neovascularization
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Author(s):
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Dr alireza baradaran rafiee, Dr azin ashnagar, Dr saeed heidari keshel, Dr mojgan rezai
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Presentation Type:
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Oral
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Subject:
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Cornea and Refractive
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Others:
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Presenting Author:
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Name:
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Azin Ashnagar
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Affiliation :(optional)
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MD,resident of ophthalmology,Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences
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E mail:
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azin_ashnagar2@yahoo.com
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Phone:
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88759469
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Mobile:
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09129378664
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Purpose:
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To compare the effect of Adiponectin versus bevacizumab on corneal neovascularization.
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Methods:
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On 20 eyes of 10 Albino rabbits, corneal neovascularization was induced by a horizontal 7-0 silk suture on 12 o’clock 1 millimeter in front the limbus. The rabbits were randomized into 2 groups. In the first group (five rabbits) the right eyes receiving (adiponectin20µg/ml bid) were compared with the left eyes receiving artificial tears as placebo. In the second group of five rabbits adiponectin drop was compared with bevacizumab (2.5mg/ml bid) for 12 days. ImageJ software was utilized to measure the length and the Area of corneal neovascularization.
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Results:
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In comparison of adiponectin and placebo the length and the area had significant reduction in adiponectin treated group (p-value <0.001). In comparison of adiponectin and bevacizumab, the mean reduction neovascularized length was %57.68 ± 19.98 and %42.49 ± 27.17 respectively( p-value 0.764).the mean reduction of neovascularized area was %70.64 ± 17.76 in adiponectin treated group and % 48.24 ± 19.23 in bevacizumab treated group( p-value 0.076).
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Conclusion:
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The result of our study showed that adiponectin drop can significantly reduce corneal neovascularization. Its effect is at least as equal as bevacizumab, although in many have clinically more significant effect.
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Attachment:
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