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مقاله
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Abstract
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Title:
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Degradation of Fibrin Sealant after Encapsulation of Human Retinal Pigment Epithelial Cells
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Author(s):
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Balagholi, Sahar1,3; Rezaeikanavi, Mozhgan1; ; Alizadeh, Shaban3; Daftarian Narsis 2; Hamid Ahmadiyeh2; Behnam Ranjbar3.
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Presentation Type:
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Poster
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Subject:
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Retina and Retinal Cell Biology
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Others:
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Presenting Author:
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Name:
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Sahar Balagholi
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Affiliation :(optional)
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1. Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran (the Islamic Republic of). 2. Ophthalmic Research Center, Shahid Beheshti University of Medica
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E mail:
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sahar_balagholi@yahoo.com
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Phone:
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Mobile:
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09367124753
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Purpose:
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To investigate degradable property of fibrin sealant after encapsulation of human retinal pigment epithelial (hRPE) cells.
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Methods:
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hRPE cells in the 4th passages were treated with 10%, 20%, and 30% fibrin sealant. Cultivated hRPE cells in 20% fetal bovine serum were considered as control. Cell-fibrin contact was determined by scanning electron microscopy on days 1, 3, and 7.
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Results:
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RPE cells encapsulated by fibrin sealant created a good cell-fibrin contact in the 1st day. However, the fibrin sealant demonstrated degradation with increasing time and had an inverse correlation with the fibrin sealant concentration (representative image).
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Conclusion:
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Fibrin sealant is degraded over time after encapsulating hRPE cells. The rate of degradation is inversely related to the fibrin concentration.
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Attachment:
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6170iravo poster 2016-Sahar.pptx
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