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مقاله
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Abstract
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Title:
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RPE degeneration model for investigation of age related macular degeneration
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Author(s):
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Hamid Aboutalebkadkhodaeian1,TakiTiraihi,*1, Hamid Ahmadieh2, HoseinziaiiArdakani2, NarsisDaftarian2
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Presentation Type:
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Poster
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Subject:
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Retina and Retinal Cell Biology
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Others:
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Presenting Author:
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Name:
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Hamid Aboutaleb Kadkhodaeean
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Affiliation :(optional)
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1Dept. of Anatomical Sciences, School of Medical Sciences, TarbiatModares University, P.O. Box 14155-4838, Tehran, Iran. 2Department of Ophthalmology Labbafinejad Medical Center Pasdaran Ave. Boostan 9
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E mail:
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habootaleb92@gmail.com
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Phone:
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Mobile:
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09128598943
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Purpose:
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We characterized changes in the visual behavior of pigmented rat in which a loss of the retinal pigment epithelium (RPE) was experimentally induced with retro-orbital venous plexus administration of sodium iodate (NaIO3).We compared and correlated these changes with alterations in neural retinal structure and function.
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Methods:
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RPE loss was induced in 250g pigmented rat with an retro- orbital sinus injection of 5% NaIO3 at two concentrations: 40, 60 mg/kg. At 1, 7, 14, 21, and 28 days (d) post injection (PI) a behavioral test was performed to evaluate visual function. Eye morphology was then assessed for changes in both the RPE and neural retina.
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Results:
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NaIO3 induced RPE degeneration was both dose and PI time dependent. Our low dose showed effects, while our high dose caused the most damage. At 7 d PI visual behavior became abnormal and patchy RPE cell loss was observed. From7 d PI onward, changes in retinal morphology and visual behavior became more severe.
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Conclusion:
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These results show that NaIO3 dosage and/or time PI can be varied to produce different, yet permanent deficits in retinal morphology and visual function.
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Attachment:
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