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مقاله
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Abstract
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Title:
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METHYLENETETRAHYDROFOLATE REDUCTASE GENE POLYMORPHISM IN PATIENTS WITH RETINAL VEIN OCCLUSION AND ANTERIOR ISCHEMIC OPTIC NEUROPATHY
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Author(s):
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Nasser Shoeibi, Ali Saadat Targhi, Majid Abrishami, SeyyedehMaryam Hosseini, Touka Banaee, Mirnaghi Moosavi
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Presentation Type:
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Oral
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Subject:
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Retina and Retinal Cell Biology
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Others:
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Presenting Author:
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Name:
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Nasser Shoeibi
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Affiliation :(optional)
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Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
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E mail:
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nshoeibi@gmail.com
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Phone:
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05117636933
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Mobile:
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09155137345
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Purpose:
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To evaluate the role of homozygosity/heterozygosity for the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C genotype in the risk of retinal vein occlusion (RVO) and anterior ischemic optic neuropathy.
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Methods:
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In a prospective study on patients younger than 50 years old with central retinal vein occlusion (CRVO), branch retinal vein occlusion (BRVO) or anterior ischemic optic neuropathy (AION) and otherwise healthy, MTHFR gene mutation was evaluated.
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Results:
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27 patients were enrolled in the study (16 males). 19 patients had CRVO, 6 patients had BRVO and 2 patients had AION. 17(63%) patients had polymorphism in one of common variant of MTHFR gene. 7 patients were heterozygote for A1298C and other were heterozygote or homozygote for C677T that common variant of MTHFR gene. 5 patients were heterozygote of two variant. 15% were homozygote. Only 48% of patients had a homocysteine level more than 11umol/L
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Conclusion:
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In otherwise healthy young patients with RVO or AION, MTHFR gene mutation can be considered a predisposing factor for vascular occlusion even in the era of normal homocysteine level in plasma.
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Attachment:
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